- Postdoctoral Fellow, Harvard Medical School, 2009-2017
- Postdoctoral Fellow, University of Oxford, 2007-2009
- D.Phil., University of Oxford, 2007
Xindan Wang
Associate Professor, Biology
- xindan@iu.edu
- 812-855-5584
- Biology Bldg. 221C
- Office Hours
Education
About Xindan Wang
Lab
Biology Bldg. 225
Awards
Indiana University Outstanding Junior Faculty Award, 2023
Indiana University Trustee’s Teaching Award, 2020
Research
Our lab is interested in chromosome dynamics in bacteria. Using Bacillus subtilis as a model organism, we combine genetic, molecular, cytological, and biochemical approaches to study how the chromosome is organized and segregated during the cell cycle. Our research primarily focuses on a set of highly conserved factors in chromosome biology, including the parABS partitioning system and the SMC condensin complex. Taking the many strengths of studying bacteria, our goal is to uncover general principles of chromosome organization and segregation in living organisms. Specific research directions include:
- Chromosome organization and segregation during the replication cycle
- Identification and characterization of novel factors involved in chromosome biology
- Molecular mechanism of chromosome packaging
- Chromosome folding during growth and development
Research areas
Chromatin, Chromosomes, and Genome Integrity
Microbial Cell Biology and Environmental Responses
Selected Publications
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Liao, Q., Brandão, H.B., Ren, Z., Wang, X. (2025) Replisomes restrict SMC translocation in vivo. Nature Communications. 2025 Aug 4;16(1):7151. doi: 10.1038/s41467-025-62596-y. PMID: 40759902
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Sanath-Kumar, R., Rahman, A., Ren, Z, Reynolds, I.P., Augusta, L., Fuqua, C, J. Weisberg, A.J., Wang, X. (2025) Linear dicentric bacterial chromosomes in Agrobacterium tumefaciens natural isolates reveal common constraints for replicon fusion. mBio. 2025 May 20:e0104625. doi: 10.1128/mbio.01046-25. PMID: 40391973.
- Ren, Z., Takacs, C.N., Brandão, H.B., Jacobs-Wagner, C., Wang, X. (2023) Organization and replicon interactions within the highly segmented genome of Borrelia burgdorferi. PLOS Genetics. 2023 Jul 26;19(7):e1010857. doi: 10.1371/journal.pgen.1010857. eCollection 2023 Jul. PMID: 37494383
- Liao, Q., Ren, Z., Wiesler, E.E., Fuqua, C., Wang, X. (2022) A dicentric bacterial chromosome requires XerC/D site-specific recombinases for resolution. Current Biology. 2022 Aug 22;32(16):3609-3618.e7. doi: 10.1016/j.cub.2022.06.050. Epub 2022 Jul 6. PMID: 35797999
- Ren, Z., Liao, Q., Karaboja, X., Barton, I.S., Schantz, E.G., Mejia-Santana, A., Fuqua, C., Wang, X. (2022) Conformation and dynamic interactions of the multipartite genome in Agrobacterium tumefaciens. PNAS. 2022 Feb 8;119(6):e2115854119. doi: 10.1073/pnas.2115854119. PMID: 35101983
- Brandão, H.B., Ren, Z., Karaboja, X., Mirny, L.A., Wang, X. (2021) DNA-loop extruding SMC complexes can traverse one another in vivo. Nature Structural & Molecular Biology. 2021 Aug;28(8):642-651. doi: 10.1038/s41594-021-00626-1. Epub 2021 Jul 26. PMID: 34312537
- Karaboja, X., Ren, Z., Brandão, H.B., Paul, P., Rudner, D.Z., Wang, X. (2021) XerD unloads bacterial SMC complexes at the replication terminus. Molecular Cell. 2021 Feb 18;81(4):756-766.e8. doi: 10.1016/j.molcel.2020.12.027. Epub 2021 Jan 19. PMID: 33472056
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