A team of IU and IUSM researchers led by Matt Bochman was recently awarded an S10 High-End Instrumentation Grant from the National Institutes of Health to purchase a C-Trap from LUMICKS. Th C-Trap is a device that combines optical tweezers with microfluidics and fluorescence and label-free microscopy to enable single-molecule biochemistry and biophysics experiments. Planned projects include analyzing the liquid-liquid phase separation of genome integrity proteins, probing the functions of DNA replication machinery, analyzing DNA repair in real time, studying ribosomal frameshifting, and determining the effects of small molecule inhibitors of quorum sensing. The equipment will be installed in a core facility and available for all IU researchers after a training period.
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