A new player in bacterial sulfide-inducible transcriptional regulation

Giedroc DP
Publication Date
August 2017
View more

Although hydrogen sulfide (H2 S) is perhaps best known as a toxic gas, the electron-rich H2 S functions as an energy source and electron donor for chemolithotrophic and photosynthetic bacteria, via sulfide oxidation, and is a universal substrate for cysteine biosynthesis. These distinct harmful and beneficial roles of H2 S suggest the need to 'sense' prevailing concentrations of sulfide and downstream reactive sulfur species (RSS) and regulate the expression of genes mediating sulfide homeostasis. The paper by Li et al. in this issue of Molecular Microbiology adds Cupriavidus FisR to an expanding repertoire of regulatory mechanisms that bacteria have evolved to sense cellular RSS and mitigate their deleterious effects.


A new player in bacterial sulfide-inducible transcriptional regulation.
Giedroc DP.
Mol Microbiol. 2017 Aug;105(3):347-352. doi: 10.1111/mmi.13726. Epub 2017 Jul 3.